Discover the invisible impact

Important Safety Information

• RYPLAZIM is contraindicated in patients with known hypersensitivity to plasminogen or other components of RYPLAZIM.
• Do not take RYPLAZIM if you have had a severe reaction to RYPLAZIM or another product containing plasminogen.
• Tell your healthcare provider about all of your medical conditions, including any medicines you take, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies.
• RYPLAZIM may worsen or prolong ongoing bleeding. In addition, if you have abnormal tissue growths because of your low plasminogen level, then you may have bleeding as these growths heal in response to treatment with RYPLAZIM.
  • If you vomit blood, have blood from your rectum or black tarry stools or any bleeding that is heavy or does not resolve after 30 minutes of direct pressure seek emergency care and discontinue further use of RYPLAZIM.
• As your lesions heal then they will fall off, known as tissue sloughing, this is in response to treatment with RYPLAZIM. This is also normal response and is not a side effect.
  • - If you have tissue growths in your airway or lungs...
  • - If you have tissue growths in your genitourinary system...
  • - If you have tissue growths in your gastrointestinal system...
  • - If you have eye lesions you may have oozing of blood...
• Notify your healthcare provider if you develop breathing difficulty, wheezing, cough, changes in speech, or pain in the back, abdomen, groin, or pelvic area...
• RYPLAZIM is made from human plasma and therefore carries a risk of transmitting infectious agents, e.g., viruses...
• You may have an allergic reaction while taking RYPLAZIM. Stop treatment and contact your healthcare provider immediately...
• In clinical trials: the most common (incidence > 10%) side effects associated with the infusion of RYPLAZIM were abdominal pain, bloating, nausea, fatigue, extremity pain, hemorrhage, constipation.